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RX TOP THERAPEUTIC CLASSES Rank Prev. Rank Therapeutic Class Claimants % of total Services Services per % Change Pharmacy Paid % of total Paid Paid per Service Pharmacy Paid Claimants 1000 PMPM 1 1 58 - ANTIDEPRESSANTS 126 25.7% 893 1,720.3 16.5% $3,120 0.8% $3.49 $0.50 2 10 17 - VACCINES 311 63.5% 531 1,023.0 185.8% $21,385 5.6% $40.27 $3.43 3 2 61 - ADHD/ANTI-NARCOLEPSY/ANTI-OBESITY/ANOREXIANTS 57 11.6% 451 868.8 28.6% $18,309 4.8% $40.60 $2.94 4 3 39 - ANTIHYPERLIPIDEMICS 48 9.8% 313 603.0 8.9% $1,456 0.4% $4.65 $0.23 5 4 44 - ANTIASTHMATIC AND BRONCHODILATOR AGENTS 58 11.8% 291 560.6 5.4% $17,884 4.7% $61.46 $2.87 6 9 36 - ANTIHYPERTENSIVES 48 9.8% 243 468.1 29.3% $763 0.2% $3.14 $0.12 7 N/A 27 - ANTIDIABETICS 16 3.3% 211 406.5 $37,219 9.8% $176.39 $5.98 8 8 90 - DERMATOLOGICALS 91 18.6% 210 404.6 8.8%% $94,048 24.8% $447.85 $15.10 9 5 25 - CONTRACEPTIVES 58 11.8% 203 391.1 -11.9% $8,510 2.2% $41.92 $1.37 10 7 72 - ANTICONVULSANTS 32 6.5% 191 368.0 -2.1% $2,396 0.6% $12.55 $0.38 Total: Selected Filter(s) 422 86.1% 3,537 6,813.9 23.3% $205,091 54.1% $57.98 $32.93 Total: All Others 335 68.4% 2,365 4,556.1 3.7% $174,234 45.9% $73.67 $27.97 Total: All 490 100.0% 5,902 11,370.0 14.6% $379,325 100.0% $64.27 $60.90 • Antidepressant prescriptions per 1000 increased 16.5% between 2020 and 2021 • Vaccines increased 185.8% • Antidiabetics were previously not on the top 10 report for 2020, but are #7 for 2021 (23% increase in scripts per 1000) • Drugs used to treat high blood pressure increased 29.3% • Overall, the # of scripts written in 2021 represents an increase of 15% from 2020. [ 10 ] [ 10

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